Reverse transcriptase families and acopia-likeretrotransposon,Osser, in the green algaVolvox carteri

Wheat retrotransposon families identified by reverse transcriptase domain analysis.

Variations in the reverse transcriptase domain were analyzed to clarify the family structure of retrotransposons in the wheat genome. Seven families were identified on the basis of the nucleotide sequence similarities of the domain. These families are common to the genomes of ancestral diploid species of wheat, evidence that they were established prior to diploid speciation, and their presence ...

The Discovery of Reverse Transcriptase

In 1961, Howard Temin began to gather evidence that was inconsistant with the central dogma. Temin, who devoted his life to studying RNA tumor viruses (now known as retroviruses), focused his early work on Rous sarcoma virus (RSV). This RNA virus is capable of transforming normal cells into cancerous cells. Temin felt the best explanation for the virus’s behavior was a model whereby the virus r...

Reverse Transcriptase and Retroviral Replication

Within each viral particle, retroviruses package two copies of a single-stranded RNA genome of about 10 kb. All of the viral genomes contain three major genes, arranged in the order: 5 ́-gag–pol–env-3 ́, and some retroviruses may also have accessory genes (e.g. vif, vpr, tax, etc...). Structural proteins such as MA (matrix protein), CA (capsid protein) and NC (nucleocapsid protein) are encoded wi...

REVERSE TRANSCRIPTASE AND cDNA SYNTHESIS

Nucleotide Reverse Transcriptase Inhibitors

4 Optimal HIV-1 suppression often is difficult to achieve and maintain with currently available antiretroviral drugs, and viral resistance eventually emerges to many drugs. Chronic antiretroviral therapy is also associated with complications such as body fat redistribution, hypertriglyceridemia and hypercholesterolemia, abnormal glucose metabolism, lactic acidosis, pancreatitis, avascular necro...